Is DnaA the 'pace-maker' of chromosome replication? An old paper revisited

Pace Maker Implantation for Elderly Individuals Over 90 Years Old

OBJECTIVE The aim of this report was to discuss validity of pacemaker surgery for elderly individuals over 90 years old. PATIENT We operated on 12 individuals over 90 years old who had syncope or congestive heart failure in association with bradycardia, between January 2005 and November 2012. METHODS All 12 patients were referred to us by the cardiology department of our hospital for pacema...

Unique and Universal Features of Epsilonproteobacterial Origins of Chromosome Replication and DnaA-DnaA Box Interactions

In bacteria, chromosome replication is initiated by the interaction of the initiator protein DnaA with a defined region of a chromosome at which DNA replication starts (oriC). While DnaA proteins share significant homology regardless of phylogeny, oriC regions exhibit more variable structures. The general architecture of oriCs is universal, i.e., they are composed of a cluster of DnaA binding s...

An unusual complication of a ventricular pace maker electrode.

DnaA- and PriA-dependent primosomes: two distinct replication complexes for replication of Escherichia coli chromosome.

Enzymatic analyses of primosome assembly at chromosomal and plasmid origins as well as that at single-stranded replication origins revealed the presence of two distinct primosomes in Escherichia coli for primer RNA synthesis and duplex unwinding. A DnaA-dependent primosome is assembled at oriC, the chromosomal origin of Escherichia coli, as well as at the A site, a single-stranded DNA hairpin c...

The bacterial replication initiator DnaA. DnaA and oriC, the bacterial mode to initiate DNA replication.

The initiation of replication is the central event in the bacterial cell cycle. Cells control the rate of DNA synthesis by modulating the frequency with which new chains are initiated, like all macromolecular synthesis. The end of the replication cycle provides a checkpoint that must be executed for cell division to occur. This review summarizes recent insight into the biochemistry, genetics an...